Coffee time! Good morning!
Framelock cut out - necessary for sure, otherwise the action will be very stiff. Titanium is very springy but there is a point where it just won't move. A really thick frame will put so much pressure on the detent ball it will barely move too. A framelock with a thinner spring will be smoother and unlock (when you want it to) with ease.
If knife has lock rock or does not engage strongly (for example a spine whack unlocks it easily) this has little to do with the lock thickness or cut out thickness. The engagement area is very small and design is the key element here.
I have tried all sorts of things as the combo between thickness and spring pressure have quite a lot to do with framelock action. .100: is roughly the cutoff for a knife to function and .070" will give you a strong lock with nice smooth action. My Ken Onion Ripple linerlock probably has a lock that is only .040" thick and the lock itself is very strong.
Weaken the frame - thicker is stronger but I feel a thicker overall frame is going to add rigidity to the knife which is important in keeping it working well
Smoothness in a folder has way more to do with the lock thickness the the bearings or washers. (but bearings allow you to crank the pivot tight for less chance of side to side play) Most of my folders have almost no friction on the blade if I press the lock spring away. Add a thicker lock and the detent pressure goes way up. This can be compensated with a very smooth face where the detent travels.
I tend to go on the side of a thicker lock, it makes sense on a framelock to me. I like thinner lock cutouts with lock bar stabilizer as once they are really thin you probably need one to avoid an accidental over opening.
The lockbar cut out - When the point the lock moves from changes the sweep of the arc will change... so with an outside cut out the arc is less, this can make a lock that is a tiny but stronger and lasts a bit longer... but not by much. Both ways are good in my opinion.
Design is the most important element in my opinion, there are so many trade off's that one must balance everything nicely.