Ever wear heavy work gloves?
Skiing/snowboarding. Winter gloves.
I'm not sure that you guys know what "ill advised" means.
Yeah, does sound pretty unlikely, but it generally involved balancing on top of a ten foot ladder trying to hold something perfectly still, while having to cut something else. Being able to open the knife with a minimum of manipulation was a big plus. My arm moved considerably less when using my thumb to nudge the AO open than when my thumb swung in the arc necessary to open my Spyderco Cricket.
Try comparing the number of muscles that end up moving when opening a blade with a Spyderhole (not bashing Spyderco, I love my Crickets) to the muscles that move when you use you use your index finger on an AO flipper or nudging the thumbstud withyour thumb.
I think even you have to admit that this scenario is ridiculously specific, but you did come up with one and that's better than I thought you would do

However I would argue that when handling something delicate, I would rather gently open a manual knife than have an AO spring out. Some of them have quite a kick.