Nanoparticles (NPs) have emerged as an effective modality for the treatment of various diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs including liposomes, polymer particles, micelles, dendrimers, quantum dots, ...
www.ncbi.nlm.nih.gov
In the past few years, there has been increasing focus on the use of messenger RNA (mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based drugs are directed toward infectious disease vaccines, cancer immunotherapies, therapeutic ...
www.ncbi.nlm.nih.gov
Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and ...
www.ncbi.nlm.nih.gov
Some good reading.
Data suggests that there are many unknown variables of mRNA vaccine delivery systems and long term affects or adaptive responses.
There is also data that suggests compromised immune systems, as well as the ability to pass these proteins to your children.
On the plus side they are cheap to make.
I think you're misreading the data quoted.
The first paper you posted is, at best, very tangentially related to any of the vaccines. It's largely just about how the medical field is tackling the challenge of appropriately delivering nanoparticle medications, mostly for cancer treatment and atherosclerosis in their examples.
The second paper pretty clearly states that mRNA vaccines have a number of advantages in safety and efficacy over not only traditional vaccines, but over other nucleic-acid based vaccines.
The last paper is the most interesting. It seems like the mRNA vaccines hit your adaptive immune system harder than initially thought, though it looks like that effect wanes significantly over time. The heritable bit that's passed down to offspring, however, is IMPROVED immune response to influenza in that particular test, while the decreased immune response to candida wasn't passed down. It also points out that the adaptive immune response can be overcome by adjuvants, like the one found in the Novavax.
It seems like the major issue is that immediately following the vaccines you may be more susceptible to other infections for a few months, which does make me wonder if that's in part responsible for the severity of the flu and RSV we're currently seeing, on the other hand, we also have a lot of data that Covid infection does lasting damage to your immune system, with reinfections making the damage worse and worse.
Now I AM very curious if that article points to the vaccines being partly responsible for the Candida Auris outbreak in Las Vegas.
All in all, I think the vaccines are more than worth the risk with what we know about Covid and long Covid. The issues with micro-clotting, strokes, cardiac events, cognitive degeneration, lowered immune response and pathological changes in the lymphatic system that they're seeing after even symptomatically mild Covid infections concern me a great deal more than the side effects we've seen with the vaccines.
I do wish Novavax was more widely available and more highly recommended, as it seems to be the most efficacious vaccine to date.