Since 2017, we drove CA to WY and back many times (maybe a dozen?) before we finally settled here. The very first time we stopped twice overnight with our airstream, afterwards we always did it in one shot.
~1200 miles with wife and two puppies, with or without different trailers, I remember my record was 17h (puppy potty breaks every 3). The drive in normal weather didn't bother me, except for 300 miles through the boring Nevada desert, in large parts it's pretty, and my wife is a good co-pilot.
It did get interesting in the winter: there are two major passes: going from CA over Reno into Nevada or vice versa (Donner Pass) and then coming either from Idaho or Salt Lake into WY (depending on what's open). I remember one drive, at 2am with trailer, driving the last two hours of a trip through a blizzard, where I couldn't see the road, and tried to stay in the middle in between snowplow sticks that they put up in winter. Another interesting one was going back to CA on a winter weekend, with black ice on Donner pass, and all the kids in their Teslas returning to the bay area from their ski week-end, many didn't know how to put chains on; trucks were losing their chains, my puppies didn't like being stopped for chain checks, etc.
Water under the bridge. I like to drive, but glad I don't have to do the above anymore.