Boy we havent had one of these for a while..... :yawn:
My two cents: I had a Para-Millie in CPM-D2 for a while and used it for the usual things. It did just fine.... I would definitely say, based on my personal experience, that it took and held an edge better than regular D2. However, I would qualify that statement by saying that the D2 knife I had was a Benchmade, and in my experience Spyderco always puts a better edge on their knives than Benchmade, out of the box.
To answer the OP's question: CPM-D2 isnt used nearly enough! Only Kershaw and Spyderco have used it, and that in a sprint run. That's production knives. As for customs, sounds like you need to speak to Danbo if you want something in CPM-D2. From what I know of his work, you wont be disappointed!