EDC knives that I carry alternate between these few:
One of my fav's is my Spyderco Time Wegner PE. The ATS-34 is easy to sharpen, and the blade shape is perfect from skinning different game to many other different tasks. The G-10 handle feels great, and doesn't slip in my hand when covered in blood or when it gets wet. Also it is large enough for self defense, easy to deploy, and solid lockup.
The other is my Emerson CQC7. This is a tough knife. I use this when working around the ranch, and I'm not scared to use/abuse it. Emerson has re-sharpened it for me once, and the edge was good as new.
Last, but not least is my Rob Simonich Bitteroot. This knife is small, but that doesn't hurt it one bit. Very sharp, and handy for small jobs. Its so light that you forget it is around your neck most of the time. Also, this awesome little knife was made by a great man that I have much respect for.