I've had a few like that...
Benchmade 530 - Has several desirable characteristics, including very lightweight, Axis lock, good steel, and great slicer grind. I just could never warm up to symmetric, dagger-like feel to the knife.
Spyderco Tenacious - Often touted as one of the top value (price to performance) knives, it has several good features (3.4" blade, G10 handles, 4-position clip, and elements from Spyderco's infamously great ergos). The knife just didn't feel like those were implemented well.It was just a bit too bulky for comfortable pocket carry, the handle and thumb ramp contours didn't fit me well, and the lack of a ricasso led to a few near accidents of closing the blade on my thumb after disengaging the liner lock.
Spyderco Native FRN - Lightweight, good size, good steel, and often credited with having great ergos. For me, though, the ergos never felt quite right. It always felt a little awkward opening (with the hole being slightly recessed into the handle), and the choil for the index finger on a choke grip just wasn't very comfortable (compared to others, like the Sage or Dragonfly).