People used to recommend that you test handguns for natural POI. Pick out a target at chest-eye level on a wall about 5 yards away, grip your handgun with the appropriate and technically correct 2 handed grip, close your eyes, pull the weapon up into an aimed position. Open your eyes and assess how close you are to aiming at the target, and how level you are holding the weapon. If you always pull a gun up and it's canted down, you will have a much harder time getting used to it during rapid fire drills than a gun that locks into place every time for you. Some handguns will fit certain individuals better than others, but you can train yourself to develop a feel for just about anything.
Revolvers are plenty good enough for home defense, but a quality semi-auto handgun with a 15+ round mag is going to be the better weapon in a home defense situation and it's going to be easier to train for.
An SBR is an order of magnitude better for home defense than either though. Only in very close quarters would a handgun be a better weapons system, and less for maneuvering and more for the shock firing a rifle in a confined bathroom makes. A rifle round will stop someone dead in their tracks, a lot of people get shot with a handgun round and run around for 3 minutes afterward - you also have a system that allows for more accuracy and quicker target acquisition when it's outfitted properly. It's more stable, and you have much better weapon retention. I wouldn't worry about shooting through 4 walls and killing the neighbors, but if you are there is ammunition to ease your fears. An SBR is head and shoulders above everything else, and even though a Shotgun is an effective weapon, putting it at the top of the list of home defense weapons makes me question your knowledge, experience, or thought processes. It offers all of the negatives and loses many of the positives of a full sized AR. Joe Biden doesn't agree, but 90% of the trained shooting community does.