Why would you attempt to use REX 121 at 59 HRC? R 121 performs best at high hardness (70+ HRC). S60V is optimized at 61~ HRC (this is way understated BTW, Shawn can explain better than I, microstructure and such, HRC is only one variable). At 61 HRC S60V is at approximately 6-7 ft/lbs toughness. Rex 121 at 70 is like 3 ft/lbs or so.
Essentially, at a working hardness (optimal for cutting) S60V has double the toughness of REX 121. RX 121 will have nearly double the edge holding ability though.
In the ratings article Larrin has REX 121 at a toughness of 1 on a 1-10 scale and an edge holding at 12 on a 1-12 scale, S60V has a toughness of 3.5 and Edge holding of 7. on a 1-10 scale.
I actually prefer S90V over both of them for EDC size fixed blades.