Price is the main deterrent for me. Once a knife hits around the $200 mark(at most), any increases in tolerances or whatnot are gonna be so miniscule that they're undetectable without specialized instruments and make absolutely no practical difference, so knives like CRK and Hinderer essentially come down to paying for the name and "prestige of ownership" rather than any actual increase in quality, which makes them a no go for me. Not saying they're bad knives, they're just not worth the price to me as I can get literally the exact same level of performance(if not better) from a good Spyderco.
Other things I might dislike, but most aren't deal breakers. I normally want a decent steel, but I'll buy an occasional cheap 440A knife(like those $4 Walmart knives from a year or so back) to leave in the glove box and side compartments in the car, carry with me if I'm going to a concert or something where I don't know if knives are allowed or not(so if it gets confiscated, no big deal), loan to friends, etc. I dislike opening holes, but it hasn't stopped me from buying multiple Spydercos. Not a fan of metal handles, but I have several Leeks, a Skyline with aftermarket Ti scales, and a couple of others. Prefer plain edges(and full serrated edges for that matter) to combo edges, but I have a couple combo edged blades around...really, price is the main deal breaker for me.
Oh, and prior bad experience. I won't buy another MTech folder as every one I've tried has suffered a wide variety of issues, including poor lockup and lock failures, massive blade play, etc. So now, even if I'm in the market for a super cheap folder, I won't go for an MTech. Oddly enough, I've had some good experience with their fixed blades, so I'm still willing to pick them up, if I'm looking to pick up a new budget fixed blade, but the folders are a total skip for me.